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Some 486 deaths were linked to the heroin-substitute methadone, taking the mortality rate for men from the drug from 9.9 deaths per million of the population in 2010 to 13.5 - a 36% rise and the highest rate since 1997.The mortality rate for women from methadone was also up slightly to 4.3 deaths per million of the population.

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Related:
Deaths related to drug poisoning in England and Wales, 2011

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